Low Dose Naltrexone
Low Dose Naltrexone (LDN) has become an innovative way to help patients and has evidence to treat many conditions. It is a safe,
non-toxic and inexpensive drug that helps regulate a dysfunctional immune system, reduces pain, and fights inflammation.
Fundamental principles to consider that LDN works on include:
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The presence of opiate receptors in multiple human body systems which regulate various biological functions from natural opiate release such as endorphins.
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Proteins called toll-like receptors (TLRs) which are part of the immune system and provide defense against pathogen invasion activating endogenous signaling molecules.
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Low-dose antagonistic activity at both of these receptor groups to help suppress unwanted immune activity or reactions.
For the latest information and research, check out the link below:
Here are direct links to informational webinars and documentaries regarding LDN:
(Webinar Link) https://ldnresearchtrust.org/ldn-webinars
(Documentaries Link) https://ldnresearchtrust.org/ldn-documentaries
Clinical trial abstracts for research studying the use of LDN in various medical conditions:
https://ldnresearchtrust.org/ldn-clinical-trials
LDN for pain research articles:
https://ldnresearchtrust.org/content/ldn-and-pain-articles
You can print off articles to bring with to discuss at appointments with your primary care providers or see our Providers Page for practitioners who we work with to potentially prescribe LDN for you.
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LDN is used to treat cancers, autoimmune diseases, chronic pain and mental health issues, to name a few. Treatment is constantly evolving, with new conditions and methods of treatment being shared regularly.
How Can
LDN Help You?
Cardiac (heart) diseases
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Autoimmune cardiomyopathy
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Dressler’s syndrome
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Kawasaki’s disease
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Polyarteritis nodosa
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Pyoderma gangrenosum
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Subacute bacterial endocarditis (SBE)
Chronic Pain
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Complex Regional Pain Syndrome/RSD
Dermatologic (skin) diseases
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Alopecia areata
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Anti-synthetase syndrome
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Atopic allergy
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Atopic dermatitis
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Autoimmune progesterone dermatitis
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Autoimmune thrombocytopenic purpura
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Autoimmune urticaria
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Bechet’s syndrome
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Blau syndrome
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Bullous pemphigoid
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Cicatricial pemphigoid
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Cutaneous leukocytoclastic angiitis
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Dego’s disease (thrombotic vasculopathy)
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Dercum’s disease
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Dermatitis herpetiformis
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Dermatomyositis
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Diffuse cutaneous systemic sclerosis
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Discoid lupus erythematosus
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Eczema
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Epidermolysis bullosa acquisita
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Erythema nodosum
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Essential mixed cryoglobulinemia
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Hailey – Hailey Disease
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Henoch-Schonlein purpura
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Herpes gestationis
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Kawasaki’s disease
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Lichen planus
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Lichen sclerosus
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Linear IgA disease
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Majeed syndrome
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Microscopic polyangiitis
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Morphea Mucha-Habermann disease
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Parry Romberg syndrome
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Pemphigus vulgaris
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POEMS syndrome
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Psoriasis
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Pyoderma gangrenosum
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Schnitzler syndrome
Ears, Nose, Sinus, Throat
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Autoimmune inner ear disease
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Churg-Strauss syndrome
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Cogan syndrome
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Ménière’s disease
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Susac’s syndrome
Endocrine diseases
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Addison’s disease
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Autoimmune polyendocrine syndrome
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Cushing’s syndrome
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Diabetes mellitus type 1
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Graves’ disease
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Hashimoto’s thyroiditis
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Hypoglycaemia
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Hypopituitary or Secondary adrenal insufficiency
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Hypothalamic Dysfunction
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Hypothyroidism
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Ord’s thyroiditis
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POEMS syndrome
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Schmidt syndrome
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Thyroiditis
Gastrointestinal diseases
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Autoimmune hepatitis
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Autoimmune enteropathy
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Autoimmune pancreatitis
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Celiac disease
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Churg-Strauss syndrome
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Crohn’s disease
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Eosinophilic gastroenteritis
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Gastritis
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Gastrointestinal pemphigoid
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Lupoid hepatitis
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Nonalcoholic steatohepatitis (NASH)
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POEMS syndrome
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Polyarteritis nodosa
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Primary biliary cirrhosis
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Primary sclerosing cholangitis
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Pyoderma gangrenosum
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Schnitzler syndrome
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Ulcerative colitis
Hematologic/blood marrow disorders
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Agammaglobulinemia
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Antiphospholipid syndrome
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Autoimmune aplastic anemia
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Autoimmune hemolytic anemia
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Autoimmune lymphoproliferative syndrome
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Castleman’s disease – lymph node hyperplasia
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Cold agglutinin disease
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Evan’s syndrome
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Majeed syndrome
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Paroxysmal nocturnal hemoglobinuria (PNH)
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Pernicious anaemia
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Pure red cell aplasia
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Pyoderma gangrenosum
Hepatology (Liver)
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Hepatitis C
Immunology
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Common Variable Immunodeficiency
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Epstein Barr Virus
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Pernicious Anemia
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Vitiligo
Infectious diseases
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Complement component 2 deficiency – increase risk of infections
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HIV
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Hypogammaglobulinemia – leads to infections
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Lyme Disease
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PANDAS (Pediatric autoimmune neuropsychiatric disorders associated with Streptococcal infections)
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Sydenham chorea
Malignancies/cancers
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Bladder Cancer
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Breast Cancer
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Carcinoid Colon & Rectal Cancer
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Glioblastoma
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Liver Cancer
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Lung Cancer (Non-Small Cell)
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Lymphocytic Leukemia (chronic)
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Lymphoma (Hodgkin’s / Non-Hodgkin’s)
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Malignant Melanoma
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Multiple Myeloma
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Neuroblastoma
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Ovarian Cancer
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Pancreatic Cancer
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Prostate Cancer (untreated)
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Renal Cell Carcinoma
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Throat Cancer
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Uterine Cancer
Neurologic diseases
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Acute disseminated encephalomyelitis
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Acute hemorrhagic leukoencephalitis
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Amyotrophic Lateral Sclerosis
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Anti-mag IgM peripheral neuropathy
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Autoimmune peripheral neuropathy
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Bickerstaff’s encephalitis
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Charcot Marie Tooth syndrome
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Chronic inflammatory demyelinating polyneuropathy
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Cranial arteritis
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Guillain-Barré syndrome
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Hashimoto’s encephalitis
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Idiopathic inflammatory demyelination
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Inflammatory demyelinating polyneuopathy
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Lambert-Eaton myasthenic syndrome
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Miller-Fisher syndrome
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Multiple Sclerosis
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Myalgic Encephalomyelitis
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Myasthenia gravis
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Neuromyelitis optica
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Neuromyotonia
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Opsoclonus myoclonus syndrome
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PANDAS
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Paraneoplastic cerebellar degeneration
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Parkinson’s disease
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Parry Romberg syndrome
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Parsonage-Turner syndrome
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Perivenous encephalomyelitis
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POEMS syndrome
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Polyarteritis nodosa
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Progressive inflammatory neuropathy
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Rasmussen’s encephalitis
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Restless leg syndrome
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Stiff person syndrome
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Susac’s syndrome
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Sydenham chorea
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Tolosa-Hunt syndrome
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Transverse myelitis
Ocular (eye) diseases
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Autoimmune uveitis
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Balo disease/Balo concentric sclerosis
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Blau syndrome
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Cogan syndrome
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Kawasaki’s disease
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Miller-Fisher syndrome
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Neuromyelitis optica
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Ocular cicatricial pemphigoid
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Opsoclonus myoclonus syndrome
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Parry Romberg syndrome
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Pars planitis
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POEMS syndrome
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Scleritis
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Susac’s syndrome
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Sweet’s syndrome
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Sympathetic ophthalmia
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Tolosa-Hunt syndrome
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Vasculitis vitiligo
Psychological disorders
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Anxiety
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Depersonalization/Derealization Disorder (but not DID)
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General Anxiety Disorder (GAD)
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Obsessive Compulsive Disorder (OCD)
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Panic Disorder
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Postpartum Depression
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Premenstrual Dysphoric Disorder (PMDD)
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Social Phobia
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Trichotillomania
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Depression
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Dissociative Disorder
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Post-traumatic stress disorder
Pulmonary (lung) diseases
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Anti-synthetase syndrome
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Asthma Churg-Strauss syndrome
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Emphysema
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Fibrosing alveolitis
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Goodpasture’s syndrome
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Idiopathic pulmonary fibrosis
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POEMS syndrome
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Pyoderma gangrenosum
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Sarcoidosis
Renal (kidney) and urologic diseases
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Anti-GBM/TBM Nephritis
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Autoimmune Renal Neuropathy
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Berger’s disease – IgA nephropathy
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Glomerulonephritis
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Goodpasture’s syndrome
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IgA nephropathy
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Interstitial cystitis
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Microscopic polyangiitis
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Paroxysmal nocturnal hemoglobinuria
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POEMS syndrome
Rheumatologic (arthritis and autoimmune)
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Ankylosing spondylitis
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Anti-synthetase syndrome
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Chronic fatigue syndrome (CFS)
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Chronic recurrent multifocal osteomyelitis
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Complement component 2 deficiency
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CREST syndrome
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Ehlers-Danlos Syndrome
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Enthesitis-related arthritis
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Eosinophilic fasciitis
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Fibrodysplasia ossificans progressive
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Fibromyalgia
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Inclusion body myositis
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Juvenile idiopathic arthritis
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Juvenile rheumatoid arthritis
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Lupus erythematosus
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Majeed syndrome
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Mixed Connective Tissue Disease
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Morphea Myositis
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Palindromic rheumatism
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Polymyalgia rheumatica
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Polymyositis
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Psoriatic arthritis
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Raynaud phenomenon
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Reiter’s syndrome
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Relapsing polychondritis
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Retroperitoneal fibrosis
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Rheumatoid arthritis
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Rheumatoid fever
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Sarcoidosis
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Schnitzler syndrome
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Scleroderma
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Sjögren’s syndrome
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Spondylitis
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Spondyloarthropathy
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Undifferentiated connective tissue disease
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Undifferentiated spondyloarthropathy
Vasculitis
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Blau syndrome
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Churg-Strauss syndrome
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Essential mixed cryoglobulinemia
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Giant cell arteritis
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Kawasaki’s disease
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Leukocytoclastic vasculitis
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Polyarteritis nodosa
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Takayasu’s arteritis
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Temporal arteritis
Women’s Health
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Infertility
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Polycystic Ovary Syndrome (PCOS)
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